Project Overview: Cardno ChemRisk was approached to develop occupational exposure limits (OELs) for diacetyl for a national trade association in the food sector.

Our Work: The existing OEL at the time were based on epidemiological data with important limitations. We proposed an alternative method of using animal studies, including data newly released by a U.S. governmental entity that was not considered during the original OEL development. Based on our review and analyses, we developed an amended OEL to the client that better represented the existing body of literature.

Our Value: Our weight-of-the-evidence review involved over 300 publications. Additionally, we published our findings in a peer-reviewed publication.  The client was able to provide its members a practical, yet science-based, exposure limit.