U.S. EPA Science Advisory Board Discusses Draft Benzo[a]pyrene IRIS Assessment

On August 21st and September 1st, 2015, the U.S. EPA Science Advisory Board (SAB) Chemical Assessment Advisory Committee (CAAC) held a public teleconference to discuss the Draft Toxicological Review of Benzo[a]pyrene report, which was released by the EPA Integrated Risk Information System (IRIS) program in September 2014. Benzo[a]pyrene is a five-ring polycyclic aromatic hydrocarbon (PAH) that is released from natural (e.g. forest fires) and anthropogenic sources (e.g. cigarette smoke, stoves, motor vehicles, and various industrial processes) during incomplete combustion.

The SAB released their comments of the Benzo[a]pyrene report on July 24th, 2015. During the two teleconferences, the committee discussed comments on the EPA’s hazard assessment and dose-response analysis of Benzo[a]pyrene, including developmental and reproductive toxicity, cancer, immunotoxicity, and the derivation of inhalation and oral reference concentrations. The IRIS public science meeting on benzo[a]pyrene has been postponed until the SAB completes its review of the draft report. The meeting agendas, as well as links to the EPA report and SAB review, can be found here and here