IRIS Discusses Non-Cancer Health Effects of PCBs

On June 17th and 18th, 2015, the US EPA’s Integrated Risk Information System (IRIS) program held a public meeting to discuss scientific issues surrounding the non-cancer health effects of polychlorinated biphenyls (PCBs). The topics addressed included: (1) the impact of congener profile on the toxicity of PCB Mixtures (including mechanism of action), (2) the evaluation of epidemiological studies for PCB dose-response assessment, (3) potential for hazard identification and dose-response assessment for PCB exposure via inhalation, (4) suitability of available toxicokinetic models for reliable route-to-route, interspecies, and/or intraspecies extrapolation,  and (5) potential toxicokinetic models or methods to inform evaluations of human susceptibility and estimate the relationship between continuous daily maternal PCB intake and milk PCB concentrations in humans. Please see this link for more information.