AIHce 2018 - Q&A with Cardno ChemRisk Scientists Part III

Posted on Behalf of  Kara Keeton

Please read below for more information from Kara Keeton on her presentation.

1.  What was the title of your presentation?  

The title of my poster is “Ethylene Oxide and Human Cancer Risk: a Systematic Literature Review and Meta-Analysis.”

2.  What was the scope of your research?

Overall, there are inconsistent findings between the toxicological and the epidemiological evidence that ethylene oxide (EO) exposure is associated with the development of breast cancer and/or lympho-hematopoietic cancers. As it’s been almost 20 years since the last comprehensive review was conducted, we performed an updated systematic review of the literature and a meta-analysis to evaluate the current body of available epidemiological evidence regarding the carcinogenicity of EO.

3.  What did you find?

The qualitative systematic review of the literature demonstrated that earlier epidemiological studies of EO were limited by factors such as small population size and/or observed number of deaths, insufficient follow-up, low EO exposure potential, lack of individual exposure data or exposure-response analysis, inconsistencies in histopathological classification of diagnoses over time, as well as the lack of latency analysis and/or the inability to account for potentially confounding factors. This was supported by our meta-analysis when the data was stratified by decade of publication, as there was a reduction in the pooled risk estimates and improved precision in the later decades, as compared to earlier decades. The more recent and more informative studies do not support the conclusion that occupational exposure to EO is associated with an increased risk of LHC.

4.  What are the next steps / what other research is need?

It would be beneficial to extend the follow-up and update previously evaluated occupational cohorts to identify any potential long-term carcinogenic effects of EO.

 

For more information, please contact Ms. Kara Keeton.